
A Novel Sensor to Reveal COVID-19 “hidden” Infection Symptom
Currently, only symptomatic cases of COVID-19, caused by the pathogen 2019-nCoV, are being identified and isolated. A large percentage of these cases lack the typical known symptoms of fever, fatigue, and dry cough. Furthermore, COVID-19 carriers can remain asymptomatic during the incubation period and thus facilitate community spread. In Canada, as of July 6, only 2,940,925 people (~7.82% of the population) have been tested for COVID-19, with more than 105,536 positive cases identified. Given that as many as 33%–41% of all COVID-19 cases lack the known symptoms, up to an estimated 34,826–43,269 cases could be asymptomatic and likely endangering public health. Early detection and isolation of COVID-19 cases, especially asymptomatic cases, remains an unmet challenge and is therefore crucial for controlling this outbreak and future hazards. In short, a novel method to identify asymptomatic cases is urgently needed. We aim to realize a rapid testing solution by developing a new sensing technology to identify asymptomatic and presymptomatic cases through early detection of a “hidden” symptom using the saliva sample. Our COVID-19-related research is supported by CMC and Mitacs Accelerate funding to develop a safe, low-complexity, rapid, and easy-to-use at-home sensing device (with mass-production potential) for the early detection of infection as a reliable symptom to isolate COVID-19 cases. The proposed technology—encompassing bioengineering, microelectronic open-JFET, computer vision, deep learning techniques—will allow accurate testing of saliva at home using a portable sensor communicated with cloud computational platform that can evaluate disease progress or treatment.
Industry Partner(s): CMC Microsystems
Academic Institution: York University
Academic Researcher: Gafar-Zadeh, Ebrahim
Platform: GPU
Focus Areas: COVID-19


Industry Partner(s): Replica Analytics Ltd.
Academic Institution: University of Alberta
Academic Researcher: Kong, Linglong
Platform: GPU, Parallel CPU


Active learning for automatic generation of narratives from numeric financial and supply chain data
Large enterprises compile and analyze large amounts of data on a daily basis. Typically the collected raw data is processed by financial analysts to produce reports. Executive personnel use these reports to oversee the operations and make decisions based on the data. Some of the processing performed by financial analysts can be easily automated by currently available computational tools. These tasks mostly make use of standard transformations on the raw data including visualizations and aggregate summaries. On the other hand automating some of the manual processing requires more involved artificial intelligence techniques.
In our project we aim to solve one of these harder to automate tasks. In fact analyzing textual data using Natural Language Processing (NLP) techniques is one of the standardized methods of data processing in modern software tools. However the vast majority of NLP methods primarily aim to analyze textual data, rather than generate meaningful narratives.
Since the generation of text is a domain-dependent and non-trivial task, the automated generation of narratives requires novel research to be useful in an enterprise environment. In this project we focus on using numerical financial and supply chain data to generate useful textual reports that can be used in the executive level of companies. Upon successful completion of the project, financial analysts will spend less time on repetitive tasks and have more time to focus on reporting tasks requiring higher-level data fusion skills.
Industry Partner(s): Unilever Canada Inc.
Academic Institution: Ryerson University
Academic Researcher: Ayse Bener
Co-PI Names: John Maidens
Focus Areas: Advanced Manufacturing, Digital Media


Advancing microarray analysis with GPU-based image analysis
Multiplexed tests detect multiple analytes from a single biological specimen in an automated fashion using microarrays. These can be used to determine patient immune response with minimal invasiveness and to better quantify biomarkers for advanced biological tests. To do this, microarrays require the printing of biological and chemical materials onto an optically transparent substrate (this require dispensing, curing, putting down a protective coating that is then dried to create a plate). Each well contains multiple spots (sensors) to detect different proteins. The proposed work improves analytical tools with a focus on accuracy, significantly decreased time to results and advanced image analysis using capability provided by SOSCIP. The SOSCIP platforms allow testing new approaches using cloud-based analysis as well as develop tools necessary for in-house analysis. The work will enhance the performance of current assay designs and inform the next generation of assays to support the partner’s technology leadership position. The results will be implemented immediately by the industry partner – as has been done in the previous work. The impact will be to place SQI in a unique market position in the diagnostics market. Ultimately, this work aligns with the partner’s goal of “cheaper, better, faster”.
Industry Partner(s): SQI Diagnostics
Academic Institution: University of Toronto
Academic Researcher: Pierre Sullivan
Platform: GPU, Parallel CPU
Focus Areas: Advanced Manufacturing, Health


Advancing sustainable aerodynamic solutions with improved modeling
Within current aerospace design, it is necessary to over-engineer features to ensure stability and safety under emergency conditions. It would be ideal to develop capabilities to reduce the size of large elements of commercial aircraft with reliable technologies that ensure safe operation under hazardous conditions. A key advantage of the synthetic jet is that no bulky air source and supply system is required to provide actuation to the flow. The planned changes to the aircraft structure that increase fuel economy and reduce weight will ensure the success of the economically important Canadian aerospace industry.
Industry Partner(s): Bombardier Inc.
Academic Institution: University of Toronto
Academic Researcher: Pierre Sullivan
Platform: GPU, Parallel CPU
Focus Areas: Advanced Manufacturing, Energy


AI-Powered Virtual Shopping Marketplace Platform for the Hair Integrations Industry
The average wig industry revenue over the last five years has a steady growth to $415.2 million per year. This industry caters to four distinct consumer groups: 1) individuals that purchase wigs for aesthetic purposes, 2) those that have lost their hair due to a medical condition or treatment, 3) those that follow their religious practice for specific hair restrictions, and 4) film/theatre directors who purchase wigs as part of character costumes. A wig costs from $600 to $1500 or more. In addition, with the COVID-19 outbreaks, online shopping inevitably became the leading trends.
However, shopping for a perfect wig online is not an easy task. We will build an AI-powered marketplace to solve the problem. In the AI-powered marketplace, customers get expert advice from AI as if customers are served by domain experts. AI will extract customers’ head shape, skin tone, and personality from the image and video, and make the best recommendations.
Industry Partner(s): Essence Luxe Couture
Academic Institution: York University
Academic Researcher: Shengyuan, (Michael) Chen
Platform: GPU
Focus Areas: Advanced Manufacturing, Business Analytics


Application of advanced machine learning and structure-based approaches for repurposing & discovering therapeutics for COVID-19
The novel COVID-19 pandemic caused by SARS-CoV-2 is a global health emergency of international concern with an estimated death toll in millions worldwide. The development, testing and approval of the COVID-19 vaccine may take at least 12-18 months. By then, the virus could mutate and reduce the vaccine’s efficacy. This project aims to leverage the latest advances in AI to repurpose existing drugs and identify novel ones that could be further developed as COVID-19 therapies in an extremely condensed manner. We will utilize Apollo 1060, 99andBeyond’s AI-augmented decision-making platform that can rapidly search a chemical space that is orders of magnitude larger than competitors. We will collaborate with experimentalists, and aim to have a set of compounds confirmed in a set of in vitro COVID-19 assays within the next six months. The proposed set of compounds and their corresponding biological activity will be openly published to help the community build powerful predictive models for COVID-19 targets. Their further testing and development will require the engagement of collaborating physicians in the hospitals and may attract partnerships with leading pharma and biotech in the US and Canada.
Industry Partner(s): 99andBeyond Inc.
Academic Institution: University of Toronto
Academic Researcher: Gennady Poda
Platform: GPU


Big cardiac data
We propose to develop a cloud based image centered informatics system powered by newly developed big data analytics from our group for automatic diagnosis and prognosis of heart failure (HF). HF is a leading cause of morbidity and mortality in Ontario and around the world. There is no cure. Therefore early diagnosis and accurate prediction is very critical before the symptoms appears. However, previously lack of efficient image analytics tool has been the major pitfall to have an accurate prognosis and early diagnosis system. The system will greatly improve the clinical accuracy and enables accurate early diagnosis and prediction by intelligently analyzing all associated historical images and clinical reports. The final system will not only greatly reduce the sudden death and irreversible cardiac conditions, but also offers a great optimization of decision system in current healthcare. This project is based on strength built upon one successful SOSCIP project and two OCE projects.
Industry Partner(s): London X-ray Associates
Academic Institution: Western University
Academic Researcher: Li Shuo
Focus Areas: Cybersecurity, Health

Big data analytics for the maritime internet of things (IoT)
The Internet of Things (IoT) is an emerging phenomenon that enables ordinary devices to generate sensor data and interact with one another to improve daily life. The maritime world has not escaped to the influence of the IoT revolution. We are in the midst of a technological wave in which vessels are not the only ones carrying sensors (GPS or radar) anymore, but other maritime entities such as cranes, crates, boats, pickup trucks, etc. are being equipped with the same capabilities. This trend constitutes the backbone of the so-called Maritime Internet of Things (mIoT).
This project is about exploiting the tide of sensor data emitted by a myriad of maritime entities in order to improve both internal and collaborative processes of mIoT-related organizations; for instance, think of a Port Authority adjusting its berthing and unloading schedule upon receiving notice that a vessel has been delayed by harsh weather conditions. The challenge addressed by this research project is the generation of actionable intelligence for Decision Support using Big Data analytics. Actionable intelligence includes anomalies, alerts, threats, potential response generation, process refinement and other types of knowledge that improve the efficiency of a maritime-related organization and/or the manner in which it interacts with other similar organizations.
Industry Partner(s): Larus Technologies Inc.
Academic Institution: University of Ottawa
Academic Researcher: Emil Petriu
Focus Areas: Advanced Manufacturing

Change Your Game
Tracking athletic performance in basketball can require significant time and resources, but the resulting information can be extremely valuable for a developing player and their coach. Fortunately, advancements in computer vision can provide an opportunity to automatically track shooting performance. Further, this information can be provided to the players in an entertaining and fun gaming atmosphere to encourage player development. The objective of this project is to advance deep learning algorithms to provide real-time biomechanical feedback that can be used to develop training and entertainment software for youth basketball players. This exciting work by Pipeline Studios Ltd., in collaboration with McMaster University, involves the use of deep learning-based approaches to track shooting mechanics and performance. Significant computational resources are initially required to test the limits of these deep learning models for image classification, object detection, event detection, and human pose estimation. The advancement of these algorithms on large computational networks will be required for the training and entertainment software which can support basketball athlete development in Canada.
Industry Partner(s): Pipeline Studios INC.
Academic Institution: McMaster University
Academic Researcher: Dylan Kobsar
Platform: GPU
Focus Areas: Health



Computational high-throughput screening of catalyst materials for renewable fuel and feedstock generation
According to a World Energy Council Report, population growth and rising standards of living across the world will at least double global energy demand by 2050. Simultaneously, carbon dioxide emissions must be reduced significantly to prevent a catastrophic rise in global temperatures. Clean and abundant renewable energy sources are available; unfortunately, the intermittency of solar and wind power is a prevailing problem which is limiting the potential for widespread use. Our project seeks to address both of these issues through development of novel catalysts to electrochemically convert CO2 captured from power plants into fuels and other higher value chemical feedstocks using renewable electricity. This innovative strategy will (1) provide a long term storage solution by converting renewable electricity into a stable chemical fuel, (2) provide a means to intelligently recycle CO2 rather than storing it in deep underground aquifers, and (3) provide a cleaner and cheaper pathway for production of industrial chemical feedstocks and fuels. This could be a truly disruptive technology which would allow Canadian led manufacturing of high value chemicals and fuels in a low-cost and low-carbon fashion. Additionally, there are large benefits to Canada’s energy sector by facilitating the dispatchability of renewable power.
Industry Partner(s):
Academic Institution: University of Toronto
Academic Researcher: Ted Sargent
Co-PI Names: Aleksandra Vojvodic
Platform: Cloud, GPU, Parallel CPU
Focus Areas: Advanced Manufacturing, Clean Tech, Energy

Computer aided diagnosis of COVID-19 symptoms using medical sensors
The challenge that currently has arisen because of COVID is that in-person appointments with doctors are not possible and everyone has to use Telemedicine. Though Telemedicine is a great convenience, the problem with current Telemedicine systems is that they cannot be used to virtually examine patients and identify if COVID-19 symptoms are present. The main reason for this is because our current Telemedicine systems lack integration with medical devices that allow capturing physiological signals over the web. We are working towards integrating these medical devices into Telemedicine platforms so that the diagnostic utility of Telemedicine can be improved, and these platforms can be used to virtually assess patients over the web.
Our software platform integrates digital medical devices into Telemedicine video conference platforms that allows doctors to assess COVID-19 symptoms from captured physiological signals and provides large scale machine learning aided COVID screening at home. Imagine Telemedicine appointments where in addition to just consulting with your doctor via video tele-conference you can have them hear your heart/lung sounds, take your temperature, blood pressure, weight, blood oxygenation all in real-time and over the internet. We are building the software infrastructure that will allow Telemedicine platforms to seamlessly integrate the plethora of digital medical devices on the market, which enable this functionality, natively into their software ecosystems. Additionally, our platform also offers an intelligent layer of machine learning software that aids doctors in consolidating patient data, clinical decision making, computer aided diagnosis and carrying out appropriate follow-ups and referrals.
Industry Partner(s): Vinci Labs
Academic Institution: University of Toronto
Academic Researcher: Yip, Christopher
Platform: GPU
Focus Areas: COVID-19

Computer vision powered digital twin for tracking manual manufacturing processes
Over 70% of tasks in manufacturing are still manual; therefore, over 75% of the variation in manufacturing comes from human beings. Human errors were the primary driver behind $22.1 billion in vehicle recalls in 2016. Currently, when plant operators want to gain an understanding of their manual processes, they send out their highly paid industrial engineers to run time studies. These studies produce highly biased and inaccurate data that provides minimal value to manufacturing teams. This project aims to develop a computer vision powered digital twin prototype that is ready to test on the client’s site, which helps manufacturing plant operators gain unprecedented visibility into their manual production operations, allowing them to optimize their worker efficiency while maximizing productivity. This will be done by automated data generation using computer vision, conversion of raw data into useable information, visualization of information using standard Business Intelligence methodologies and lastly, prediction of future plant performance based on historical information, as well as information about other market drivers.
Industry Partner(s): IFIVEO CANADA INC.
Academic Institution: University of Windsor
Academic Researcher: Afshin Rahimi
Focus Areas: Business Analytics


Continuous vital sign monitoring using intelligent bed sheet
Studio 1 labs developed wireless intelligent bed sheet patient monitoring system that continuously captures client vital signs. In collaboration with Dr. Laura Nicholson and York University’s Faculty of Health, Studio 1 labs will work with SOSCIP infrastructure to match vital signs with gold standards approved medical decides for the highest level of accuracy through clinical validation and scientific evidence. With millions of data points collected from each device to output clinical grade quality information continuously, AI solutions allow modeling to predict health emergencies and diseases. This contributes to efficient health monitoring solutions that are simple and effective for use by older adults and healthcare providers.
Industry Partner(s): Studio 1 Labs Inc.
Academic Institution: York University
Academic Researcher: Laura Nicholson
Focus Areas: Advanced Manufacturing, Health

COVID-19 AI based screening and monitoring of COVID-19 respiration patterns using acoustic sensors
This project addresses the pressing need for remote monitoring of long-term care homes to ensure potential cases of COVID-19 are identified early, isolated and treated.
Ryerson University’s Xiao-Ping Zhang, in concert with Altum View Systems Inc., will develop AI-based algorithms and systems to screen and monitor acoustic respiration patterns for COVID-19 in real-time, using customer mobile devices (e.g., mobile phones, wireless headphones, smart wrist-watches, etc.), low-cost electronic stethoscopes, and professional respiration monitor diagnostic devices. The COVID-19 acoustic respiration pattern screening and monitoring system will be incorporated into and complement Altum View Systems Inc.’s current camera-based health monitoring system for home care and long-term care facilities.
Industry Partner(s): AltumView Systems Inc.
Academic Institution: Ryerson University
Academic Researcher: Zhang, Xiao-Ping
Focus Areas: COVID-19




Industry Partner(s): Lytica Inc.
Academic Institution: University of Ottawa
Academic Researcher: Burak Kantarci
Focus Areas: Advanced Manufacturing, AI, Business Analytics, Supply Chain



Design of OLED materials for manufacturing and improved product quality
Organic light emitting diodes (OLEDs) present a unique opportunity to produce thinner and more efficient lighting and displays. This will change the way we interact with light. The main barrier to mass adoption of OLEDs is the manufacturing process, due to the need for high throughput while maintaining nanoscale precision. High throughput operation requires materials that can undergo elevated temperature without decomposing. Our objective is to use computational chemistry to model innovative materials that can withstand these elevated temperatures while still providing high performing OLEDs. We will simulate targeted compounds using SOSCIP’s computer cluster examining properties relevant to OLED manufacturing processes. Promising materials will be synthesized and their properties experimentally measured then compared to the simulation results. The most promising materials will then be integrated into OLEDs and characterized by OTI Lumionics in their pilot scale manufacturing line located in Toronto, ON.
Industry Partner(s): OTI Lumionics Inc.
Academic Institution: University of Ottawa
Academic Researcher: Benoit Lessard
Platform: GPU, Parallel CPU
Focus Areas: Advanced Manufacturing, Clean Tech, Energy

Designing Pan-Coronavirus Therapeutics by Multi-Species DTI Interaction Modeling
COVID-19 has had an unprecedented impact on modern society and economic systems. The scale and severity of this pandemic calls for a global, multi-tiered deployment of all available biotechnology platforms in search of therapeutics. While ongoing global vaccine and drug repurposing trials provide hope moving into Fall2020, we must continue to prepare multiple lines of defense in anticipation of new emergent strains.
Emerging Canadian biotech company Cyclica will partner with Matthieu Schapira from the Department of Pharmacology & Toxicology and the Structural Genomics Consortium at the University of Toronto to design a new line of pan-coronavirus inhibitors. This collaboration will discover new druggable, well-conserved sites on coronavirus protein surfaces and perform an AI-based virtual screen in search of chemical inhibitors, using Cyclica’s Match Maker engine.
The SOSCIP GPU-accelerated platform will be used to broaden Match Maker’s domain of applicability to non-human species by augmenting training with protein-ligand binding data from multiple species and re-optimizing neural networks. This collaboration will lead to new viral targeting strategies and a new platform to address emerging threats.
Industry Partner(s): Cyclica
Academic Institution: University of Toronto
Academic Researcher: Schapira, Matthieu
Platform: GPU
Focus Areas: COVID-19

Development of a COVID-19 in pregnancy data respository and prognostication algorithm
Professors Dafna Sussman & Rasha Kashef of Ryerson University are teaming up with Mount Sinai Hospital to tackle the very difficult problem of achieving successful early intervention for pregnant women diagnosed with COVID-19.
The project aims to support medical professionals who are directly treating COVID-19 pregnancies. A comprehensive, anonymized data repository will be deployed in conjunction with dedicated prediction algorithms to score patients for their risk of severe deterioration. The repository together with the algorithm are expected to radically transform Canadian and, potentially, international healthcare providers’ ability to identify, manage and treat cases of COVID-19 in pregnant patients.
Industry Partner(s): Mount Sinai Hospital
Academic Institution: Ryerson University
Academic Researcher: Sussman, Dafna
Focus Areas: COVID-19

Development of severity index of exacerbation for COVID-19 symptoms from abnormal respiratory patterns
Struggling to breathe has been a challenge that existing monitoring devices have faced, for identifying early symptoms of respiratory diseases such as novel Coronavirus (COVID-19). Measuring respiratory rate alone would result in potentially missing if a patient was unable to inhale a full breath.
To overcome this challenge, a novel technology solution invented in Canada is used through an Intelligent Bed Sheet, with the ability to continuously monitor if a patient has normal, shallow, or irregular breathing.
This collaboration with York University will revolve around developing a Severity Index by identifying earlier when a patient is struggling to breathe. Using the most advanced electronic fabric technology, the SOSCIP Platform will support computing challenges by using large amounts of breathing data in a constantly changing environment, to precisely identify before a patient’s breathing becomes more severe.
Industry Partner(s): Studio 1 Labs Inc.
Academic Institution: York University
Academic Researcher: Steven Wang
Focus Areas: COVID-19